IMSC 2014

20th International Mass Spectrometry Conference

Join us at IMSC to discover how scientists and researchers are transforming quantitation with mass spectrometry solutions.

Visit us at Booth 23. Meet with our experts to discuss how we can partner with you to solve some of your toughest analytical challenges, collect poster notes tailored to your applications interests and request a 1-on-1 software demonstration to discover new ways to enhance your productivity.

Attend free technical seminars

Register for our lunchtime seminars to learn more about the latest research to routine solutions in mass spectrometry in small focused groups.

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Yes, I would like to meet with an expert to help me solve challenges in my laboratory while I'm at IMSC.

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The 2014 Curt Brunnée Award

Wednesday, August 27 | 8:00 – 8:45 (During the Plenary Session 4)
Sponsored by Thermo Fisher Scientific

The 2014 Curt Brunnée Award will be awarded to Dr. Dimitris Papanastasiou for his contributions to the development of the theoretical understanding of ion behaviors and implementation of this knowledge in new devices for ion optics and ion mobility. Dr. Papanastasiou was nominated by the Hellenic Mass Spectrometry Society.

Seminars

Register for our lunchtime seminars to learn about the latest transformations in mass spectrometry technologies and solutions from Thermo Fisher Scientific experts and invited fellow scientists.

Lunch will be served at the close of each seminar at 13:00.

Monday – August 25, 2014

12:00 – 13:30

Definitive DIA: The Benefits of Orbitrap HRAM for Data Independent Analysis

Data-Independent Analysis (DIA) on Thermo Scientific™ Orbitrap™-based systems offers the ability to detect and quantify large numbers of proteins or small molecules in a sample by systematically collecting multiplexed MS and MS/MS data for all ionizable compounds in a sample. Several practical DIA workflow options will be discussed along with the critical benefits of data quality enabled by Orbitrap high resolution and mass accuracy.

Tuesday – August 26, 2014

12:00 – 13:30

10 Samples in One: The Magic of Multiplexed Proteomic Analysis

Tandem Mass Tag™ (TMT™) Reagents allow researchers to derive results from 10 separate samples in a single LC-MS analysis, boosting lab productivity 10X and allowing proteomics results to play a critical role in large scale biological studies. Highly optimized and accurate TMT workflows have been developed for the Thermo Scientific Orbitrap Fusion™ Tribrid™ MS system. New enhancements which improve TMT performance even further will be shared in this workshop as well as a practical example of the impact of TMT reagents on quantitative biology in a collaborative lab.

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Wednesday – August 27, 2014

12:00 – 13:30

A Really Big Challenge: Quantitative Characterization of Protein Therapeutics

Protein therapeutics are large, heterogeneous molecules, yet it is possible to characterize them precisely and quantitatively with mass spectrometry. This workshop will discuss how Orbitrap mass spectrometry can be used to generate essential structural information on proteins and protein complexes, as well as sites of modification for a comprehensive understanding of your protein drug or drug conjugate.

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Products

Succeeding in science often depends on how precisely you match your tools to your challenges. Complete, dependable solutions are critical when time and expense mean everything.

Q Exactive HF Benchtop Orbitrap Mass Spectrometer

The Thermo Scientific™ Q Exactive™ HF mass spectrometer is the next generation bench top system with an ultra High Field Orbitrap detector, providing speed, productivity and confidence for both qualitative and quantitative omics workflows

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Orbitrap Fusion Tribrid Mass Spectrometer

The Thermo Scientific™ Orbitrap Fusion™ mass spectrometer with its revolutionary Tribrid™ architecture provides unprecedented depth of analysis for complex biological challenges. The new 1.1 Instrument Control Software and operating modes bring powerful new features to enable researchers to focus on their science rather than experimental setup

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Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

The Thermo Scientific™ Q Exactive™ Plus benchtop LC-MS/MS combines high performance quadrupole precursor selection with high-resolution/accurate mass (HR/AM) Orbitrap™ detection to deliver high performance and tremendous versatility, to characterize, quantify, and confirm in a single analysis.

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Exactive Plus EMR Orbitrap LC-MS System

The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines high-resolution accurate-mass (HR/AM) Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.

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Exactive Plus Orbitrap Mass Spectrometer

The Thermo Scientific™ Exactive™ Plus mass spectrometer combines high-resolution/ accurate-mass (HR/AM) Orbitrap™ analysis for a wide range of applications. From protein characterization to targeted or DIA-based quantitation and confident DMPK qual/quan screening studies, this system enables you to screen, identify and quantify compounds in complex samples rapidly.

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Orbitrap Elite Hybrid Ion Trap-Orbitrap Mass Spectrometer

The Thermo Scientific™ Orbitrap Elite™ hybrid mass spectrometer raises the bar for MS and MSn performance and versatility by combining our premier linear ion trap mass spectrometer with a novel high-field Orbitrap™ mass analyzer. The system delivers greater than 240,000 resolution (FWHM), increased sensitivity, high scan speeds and a larger dynamic range.

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Q Quantiva Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantiva™ Triple quadrupole mass spectrometer with Active Ion Management (AIM) technology delivers unrivaled sensitivity, speed, and dynamic range for scientists facing the most difficult quantitative challenges now and in the future. This extreme performance is achieved with a reliability and ease of operation that help users spend more time thinking about their analyses and less time worrying about instrument setup and operation.

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TSQ Endura Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Endura™ Triple quadrupole mass spectrometer provides unparalleled value, with LODs and LOQs unrivaled in its class. It delivers this best-in-class quantitation run-after-run and day-after-day regardless of sample type or matrix, and it does so with a simplicity that takes the worry out of method development and operation.

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TSQ Quantum Access MAX Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantum Access MAX™ Triple quadrupole mass spectrometer redefines versatility, making it the value-conscious choice for a wide variety of applications, including: pharmaceutical, environmental, Food and Beverage, clinical research, and forensics. The TSQ Quantum Access MAX sets the benchmark for sensitivity in its class, providing unmatched specificity at an affordable price.

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TSQ 8000 EVO Triple Quadrupole GC-MS/MS

Expect more with the evolution of the highly successful TSQ 8000 GC-MS/MS system featuring EvoCell technology. The new Thermo Scientific™ TSQ™ 8000 EVO triple-stage quadrupole GC-MS/MS offers more MS/MS simplicity and unstoppable productivity to provide ultimate performance SRM for the high-throughput analytical laboratory.

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Prelude SPLC System

Practical, cost-effective LC-MS analysis is now ready for clinical research and forensic toxicology labs. The Thermo Scientific™ Prelude SPLC™ Sample Preparation and Liquid Chromatography system enables fast, reproducible, and reliable on-line sample preparation with high performance chromatographic separation.

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Transcend II System with Multiplexing and TurboFlow Technology

The Thermo Scientific™ Transcend™ II system, now equipped with high performance UltiMate 3000 RSLC pumps, combines Thermo Scientific™ TurboFlow™ technology for online sample cleanup of complex matrices with automated 2X or 4X multiplexing for unparalleled sample throughput in an LC system.

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Dionex ICS-5000+ HPIC System

Experience the next evolution in IC with a universal high-pressure ion chromatography (HPIC) system for capillary, microbore and standard bore applications. With Reagent Free IC (RFIC™) operation, the Thermo Scientific™ Dionex™ ICS-5000+ HPIC™ system creates the eluents so all you need to do is add water.

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Dionex UltiMate 3000 XRS System

Maximize the productivity of your LC-MS workflows. The Thermo Scientific™ Dionex™ UltiMate™ 3000 XRS system provides exceptionally high-throughput and ultra-high resolution chromatography. Use it as a front end for LC-MS setups for flexibility, excellent peak sharpness and a large sample capacity.

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Easy-nLC 1000 Liquid Chromatograph

The Thermo Scientific™ EASY-nLC™ 1000 nanoflow LC delivers sharper peaks for better resolution and increased protein coverage with accurate and precise solvent flow management. Dual flow sensors placed ahead of the mixer ensure precise gradients for reproducible results. Thermo Scientific™ Dionex™ nanoViper™ fingertight fitting system technology and a large touch screen make the system easy to set up and use.

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Versette Automated Liquid Handler

The Thermo Scientific™ Versette™ Automated Liquid Handler supports automation for MSIA workflows. Achieve fast and reproducible pipetting cycles for high-throughput assay development with Thermo Scientific™ MSIA D.A.R.T.S (Disposable Automation Research Tips).

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Finnpipette Novus i Multichannel Electronic Pipette

Thermo Scientific™ Finnpipette™ Novus i Multichannel Electronic pipettes enable reliable and continuous pipetting for affinity purification with MSIA D.A.R.T.'S in a semi-automated system for rapid sample processing. The pipette programming is further simplified through a customized MSIA menu. It is capable of processing up to 12 samples simultaneously.

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iRC Pro 1.0 Meta Calculation Software

Thermo Scientific™ iRC Pro software is an automated data processing software for SRM based data. It calculates the concentration of target analytes using mass ion ratios and performs meta calculations using user-defined formula; removing common errors in post-analytical data processing.

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PepFinder 1.0 Software

Thermo Scientific™ PepFinder™ 1.0 software is a new peptide mapping tool for the deep characterization of biotherapeutic proteins, including relative quantitation PTM's and amino acid substitutions, and location of disulfide bonds. A novel fragmentation prediction and scoring provides fast, comprehensive and confident assignments.

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LipidSearch Software

Thermo Scientific™ LipidSearch™ 4.0 software processes LC-MS data, including the high-resolution accurate-mass data generated by Thermo Scientific™ Orbitrap™-based mass spectrometers, to provide accurate lipid identification. It automatically integrates complex data into reports and dramatically reduces data analysis time.

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Proteome Discoverer Software

Thermo Scientific™ Proteome Discoverer™ 1.4 software is the most comprehensive data analysis platform for qualitative and quantitative proteomics research. It includes a faster, multi-threaded SEQUEST™ and Library Searching tool for very fast data processing, and tools like Percolator and Byonic that maximize the information from MS/MS data.

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Protein Deconvolution Sofware

Thermo Scientific™ Protein Deconvolution 3.0 software provides accurate mass measurement and isoform quantification for intact proteins such as biotherapeutics. Now includes enhanced deconvolution algorithms, support for the Exactive Plus EMR system, and mirror plots for comparison of samples.

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Pinpoint Software

Thermo Scientific™ Pinpoint™ 1.4 software is a comprehensive targeted proteomics quantitation software supporting the analysis of proteins, peptides, and now glycoproteins (N- and O-linked) of standard and data independent analysis. Automated workflows facilitate all experimental aspects, from method development and acquisition to data verification and reporting.

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TraceFinder Software

Thermo Scientific™ TraceFinder™ 3.2 software is an easy-to-use, workflow-driven software for laboratories performing quantitation and targeted screening using GC-MS and LC-MS. TraceFinder software increases productivity with powerful method development, simplified data acquisition, comprehensive data review, and extensive reporting features including custom report options

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SIEVE Software

Thermo Scientific™ SIEVE™ 2.1 software automates differential analysis of metabolites, proteins, and peptides. SIEVE software includes a new advanced algorithm for small molecule peak detection that facilitates large-scale data reduction, reduces false positives, generates elemental composition information, and displays pathway mapping for metabolomics applications.

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Mass Frontier SR2 Software

Thermo Scientifc™ Mass Frontier 7.0™ software simplifies the management, evaluation, and structural interpretation of LC-MS and GC-MS data. It offers a confident path from spectra to structure through chemically intelligent structural elucidation in metabolism, metabolomics, forensics, natural products, impurities, and degradants research.

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mzCloud Advanced Mass Spectral Database

mzCloud is a new generation of HR/AM fragmentation library. Building a comprehensive and structurally diverse spectral library requires a collective approach, with an open community of scientific and industrial partners who voluntarily provide MSn spectral trees which, through a web-based interface, can be searched without restriction. Thermo Fisher Scientific is proud to contribute HR/AM Orbitrap data to mzCloud.

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Chromeleon Chromatography Data System (CDS) Software

The Thermo Scientific™ Dionex™ Chromeleon™ 7.2 Chromatography Data System (CDS) software is the first CDS that combines separation (GC/IC/LC) and Mass Spectrometry (MS) in an enterprise environment. Chromeleon 7.2 Service Release 1 now also provides control for Thermo Scientific LC-MS instruments.

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TMT10plex Labeling Reagents

Thermo Scientific™ TMT10plex™ Labeling Reagents enable up to ten different peptide samples prepared from cells or tissues to be labeled in parallel and then combined for tandem MS analysis. The high-resolution MS/MS spectrum generated is used to measure relative protein expression levels.

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Pierce HeLa Protein Digest Standard

The Thermo Scientific™ Pierce™ HeLa Protein Digest Standard is a lyophilized tryptic peptide mixture that can be used as a quality control standard for LC separation, MS method development and MS performance benchmarking. It is specially formulated for LC-MS experiments and does not contain salts or detergents.

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Pierce Trypsin Protease, MS Grade

The ready-to-use liquid Thermo Scientific™ Pierce™ Trypsin Protease is a highly purified porcine trypsin that has been TPCK-treated to eliminate chymotryptic activity and methylated to improve stability during protein digestion.

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Pierce LysN Protease, MS Grade

Thermo Scientific™ Pierce™ LysN Protease is a MS-grade zinc metalloprotease that cleaves at the NH2-terminus of lysines, generating longer peptides than trypsin. Pierce LysN Protease is effective over broad temperature range and denaturing conditions, making it ideal for shotgun proteomics experiments.

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Fisher Chemical Specialized LC-MS Mobile Phase Blends

Fisher Chemical™ specialized solvent blends are developed for use in LC-MS, ideal for cutting-edge applications such as proteomics, metabolomics, clinical research, and drug discovery. Blends are function-tested and optimized for minimal impurities and interference-free baselines, thus maximizing performance in high-resolution and high-sensitivity LC-MS analysis.

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Fisher Chemical Improved Quality on Methylene Chloride

Through a Quality by Design approach, Optima™ and GC Resolve™ Methylene Chloride has new innovative packing, along with improved specifications based on 1000:1 concentration that will hold months after storage to ensure an interference-free baseline proven by GC-ECD, GC-FID and GC-MS.

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Fisher Chemical Solvents Specified for UHPLC-MS & UHPLC-UV

Last year, Fisher Chemical™ unveiled Optima LC-MS™ specified for UHPLC-UV. This year, a new line of Optima Acetonitrile, Methanol, and Water will be qualified for UHPLC-MS. Customers are ensured increased sensitivity, low background levels, and low metal ion content which minimizes adduct formation when running their UHPLC-MS applications.

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Virtuoso Vial Identification System

The Thermo Scientific™ Virtuoso™ Vial Identification System imprints customizable information DIRECTLY onto Thermo Scientific vials. The system provides an error-free solution to vial labeling, increased productivity and data quality with reliable vial identification.

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GlycanPac AXR-1 columns

Thermo Scientific™ GlycanPac™ AXR-1 columns enable industry-leading analysis of biologically important glycans. Their innovative mixed-mode column technology separates glycans based on charge, isomeric structure, and size. Available in multiple HPLC and UHPLC formats, they offer mass spectrometric detection of both labelled and native glycans.

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SOLAµ SPE Plates

Thermo Scientific™ SOLAµ™ plates are designed for bioanalytical and clinical research analysts who consistently require cleaner highly reproducible and robust sample extraction at very low sample volumes. Our award winning fritless SPE technology removes variability and optimizes your high throughput laboratory workflow.

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ProSwift RP-4H Capillary Monolithic HPLC Columns

Thermo Scientific™ ProSwift™ RP-4H Capillary Monolithic HPLC columns deliver fast, high-resolution separations of intact proteins and complex mixtures of large proteins. Their unique monolithic structure is designed to provide fast mass transfer, enhancing separation efficiency, delivering increased peak capacity and facilitating increased sample throughput.

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MSIA D.A.R.T.'S: Insulin, Streptavidin, and Protein A/G

Affinity purification using Thermo Scientific™ MSIA Disposable Automation Research tips (D.A.R.T.'S™) is central to the MSIA workflow. MSIA D.A.R.T.'S use a proprietary microfluidic column (contained within a functional pipette tip) that is derivatized with specific capture reagents to enable sensitive, reproducible, and confident quantification of specific analytes by LC-MS.

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Posters


The following posters will be presented at ISMC. Don't miss the opportunity to connect with our technical expert-authors and get answers to your questions.

Monday – August 25, 2014

MPS03-11

Experimental and numerical study of a two-mirror multireflectron

Author: A. Giannakopulos Session: S03 - Mass Spectrometry Instrumentation
Time: 11:00
Download
MPS02-03

Comprehensive Analysis of Extractables from Rubber Stopper used in Medical Devices and Pharmaceutical Products

Author: A. Feilden Session: S02 - Synthetic Macromolecules
Time: 11:00
Download
MPS06-44

Benefits of High Resolution and Accurate Mass Instrument for therapeutic monitoring of baclofen and its metabolites in plasma and urine.

Author: C. De Nardi Session: S06 - Clinical Applications and Screening
Time: 13:00
MPS03-10

Improvements in Shotgun Proteomics Using a Benchtop Quadrupole High-Field Orbitrap

Author: K. Strupart Session: S03 - Mass Spectrometry Instrumentation
Time: 13:00
Download

Tuesday – August 26, 2014

TPS17-17

Structure characterization and differentiation of biosimilar and reference products using unique combination of complementary fragmentation mechanisms

Author: K. Scheffler Session: S17 - Protein Phosphorylation and other Post-translational Modifications
Time: 11:00
Download
TPS12-24

Higher resolution LC-MS and MS-MS analysis of lipid extracts using benchtop Orbitrap-based mass spectrometers and LipidSearch software

Author: M. Demant Session: S12 - Lipidomics
Time: 13:00
Download

Wednesday – August 27, 2014

WPS26-57

Metabolomic Profiling of Anionic Metabolites in Oral Cancer Cells by Capillary Ion Chromatography HR/AM Mass Spectrometry

Author: M. Demant Session: S26 - Metabolomics
Time: 11:00
Download

Thursday – August 28, 2014

ThPS36-25

Quick and sensitive analysis of multiclass veterinary drug residues in animal products using a benchtop Orbitrap mass spectrometry system

Author: O. Scheibner Session: S36 - Advanced Mass Spectrometry in Food and Nutrition
Time: 11:00
ThPS36-37

Analysis of 200+ Pesticides in a Short LC Run Using Non-Timed SRMs on Triple Quadrupole Mass Spectrometer

Author: O. Scheibner Session: S36 - Advanced Mass Spectrometry in Food and Nutrition
Time: 11:00
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ThPS36-39

Fast SRM Transition Speeds for High Sensitivity, High Capacity and Selective Multi-Residue Pesticide GC-MS/MS Analysis

Author: P. Silcock Session: S36 - Advanced Mass Spectrometry in Food and Nutrition
Time: 11:00
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ThPS37-41

Identification and Relative Quantification of Anions in Battery Samples with the course of time using Ion chromatography and High Resolution Mass Spectrometer

Author: J. Lee Session: S37 - Separations Hyphenated to Mass Spectrometry, Focus on Applications
Time: 11:00
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ThPS39-11

A "Universal" data-dependent mass spectrometry method that eliminates time-consuming method optimization for achieving maximal identifications from each sample

Author: K. Scheffler Session: S39 - Informatic tools for Mass Spectrometry
Time: 11:00
Download
ThPS32-20

Separation of Lipid Classes, Subclasses and Isobaric/Isomeric Lipids Using a Novel FAIMS Device

Author: T. Settineri Session: S32 - Ion Mobility Mass Spectroscopy
Time: 13:00
Download
ThPS33-10

Structure characterization of intact monoclonal antibody using Orbitrap Tribrid mass spectrometer

Author: K. Scheffler Session: S33 - Data Analysis – General
Time: 13:00
Download

Oral Presentations

Learn about the latest transformations in mass spectrometry technologies and solutions from leading scientists as part of the IMSC Technical Program.

Monday – August 25, 2014

9:00 – 11:00

New Developments in Speeding up Orbitrap Mass Spectrometry

Novel Aspect: Combination of compact high-field Orbitrap analyzer with novel instrument control and signal processing enables significant increase of analysis speed.

Location: Room 1 Speaker: Alexander Makarov, Thermo Fisher Scientific, Germany

Wednesday – August 27, 2014

9:00 – 11:00

Sequencing of Native Protein Complexes

Native mass spectrometry (MS) is becoming an important integral part of structural proteomics and system biology research. The approach holds great promise for elucidating higher levels of protein structure; from primary to quaternary. This requires the most efficient use of tandem MS, which is the cornerstone of MS-based approaches.

Location: Room 3 Speaker: Mikhail Belov, Thermo Fisher Scientific, Germany

Customer Appreciation Event

Wednesday August 27th

If you are attending IMSC 2014 don't miss our special VIP event at CERN!

Join us for an exclusive evening at the CERN Globe, a unique facility blending modern architecture with state-of-the-art technology. CERN is the home for the European Organization for Nuclear Research, one of the world's largest and most respected centres for scientific research, also known as the European Laboratory for Particle Physics.

Enjoy a relaxed buffet dinner and be amazed by an unforgettable guided tour of the permanent interactive exhibition “Universe of Particles” housed in the Globe.

Transportation will be provided from the Conference Center and back.

This is an exclusive event open to invitation only. To secure your ticket for the evening please register as soon as possible to reserve your seat.

Register