HUPO 2014

13th Human Proteome Organization World Congress

Join us at the HUPO World Congress and learn about continued innovations in mass spectrometry technologies and solutions which are transforming proteomics research.

  • Visit us at booth #16-18
  • Register for our technical seminar where you can hear first-hand from leading researchers who will be presenting their groundbreaking and innovative work
  • View our oral and poster presentations, and discover the latest results from our in-house researchers

Our scientific experts will be available throughout the show to discuss how we can partner with you to overcome limits and cross boundaries to solve some of your toughest analytical challenges.

NEW

Q Exactive HF Benchtop Orbitrap Mass Spectrometer

The Thermo Scientific™ Q Exactive™ HF mass spectrometer is the next generation bench top system with an ultra High Field Orbitrap detector, providing speed, productivity and confidence for both qualitative and quantitative omics workflows

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Orbitrap Fusion Tribrid Mass Spectrometer

The Thermo Scientific™ Orbitrap Fusion™ mass spectrometer with its revolutionary Tribrid™ architecture provides unprecedented depth of analysis for complex biological challenges. The new 1.1 Instrument Control Software and operating modes bring powerful new features to enable researchers to focus on their science rather than experimental setup

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Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

The Thermo Scientific™ Q Exactive™ Plus benchtop LC-MS/MS combines high performance quadrupole precursor selection with high-resolution/accurate mass (HR/AM) Orbitrap™ detection to deliver high performance and tremendous versatility, to characterize, quantify, and confirm in a single analysis.

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Exactive Plus EMR Orbitrap LC-MS System

The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines high-resolution accurate-mass (HR/AM) Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.

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Exactive Plus Orbitrap Mass Spectrometer

The Thermo Scientific™ Exactive™ Plus mass spectrometer combines high-resolution/ accurate-mass (HR/AM) Orbitrap™ analysis for a wide range of applications. From protein characterization to targeted or DIA-based quantitation and confident DMPK qual/quan screening studies, this system enables you to screen, identify and quantify compounds in complex samples rapidly.

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Orbitrap Elite Hybrid Ion Trap-Orbitrap Mass Spectrometer

The Thermo Scientific™ Orbitrap Elite™ hybrid mass spectrometer raises the bar for MS and MSn performance and versatility by combining our premier linear ion trap mass spectrometer with a novel high-field Orbitrap™ mass analyzer. The system delivers greater than 240,000 resolution (FWHM), increased sensitivity, high scan speeds and a larger dynamic range.

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TSQ Quantiva Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantiva™ Triple quadrupole mass spectrometer with Active Ion Management (AIM) technology delivers unrivaled sensitivity, speed, and dynamic range for scientists facing the most difficult quantitative challenges now and in the future. This extreme performance is achieved with a reliability and ease of operation that help users spend more time thinking about their analyses and less time worrying about instrument setup and operation.

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TSQ Endura Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Endura™ Triple quadrupole mass spectrometer provides unparalleled value, with LODs and LOQs unrivaled in its class. It delivers this best-in-class quantitation run-after-run and day-after-day regardless of sample type or matrix, and it does so with a simplicity that takes the worry out of method development and operation.

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TSQ Quantum Access MAX Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantum Access MAX™ Triple quadrupole mass spectrometer redefines versatility, making it the value-conscious choice for a wide variety of applications, including: pharmaceutical, environmental, Food and Beverage, clinical research, and forensics. The TSQ Quantum Access MAX sets the benchmark for sensitivity in its class, providing unmatched specificity at an affordable price.

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Dionex UltiMate 3000 XRS System

Maximize the productivity of your LC-MS workflows. The Thermo Scientific™ Dionex™ UltiMate™ 3000 XRS system provides exceptionally high-throughput and ultra-high resolution chromatography. Use it as a front end for LC-MS setups for flexibility, excellent peak sharpness and a large sample capacity.

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Easy-nLC 1000 Liquid Chromatograph

The Thermo Scientific™ EASY-nLC™ 1000 nanoflow LC delivers sharper peaks for better resolution and increased protein coverage with accurate and precise solvent flow management. Dual flow sensors placed ahead of the mixer ensure precise gradients for reproducible results. Thermo Scientific™ Dionex™ nanoViper™ fingertight fitting system technology and a large touch screen make the system easy to set up and use.

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Versette Automated Liquid Handler

The Thermo Scientific™ Versette™ Automated Liquid Handler supports automation for MSIA workflows. Achieve fast and reproducible pipetting cycles for high-throughput assay development with Thermo Scientific™ MSIA D.A.R.T.S (Disposable Automation Research Tips).

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Finnpipette Novus i Multichannel Electronic Pipette

Thermo Scientific™ Finnpipette™ Novus i Multichannel Electronic pipettes enable reliable and continuous pipetting for affinity purification with MSIA D.A.R.T.'S in a semi-automated system for rapid sample processing. The pipette programming is further simplified through a customized MSIA menu. It is capable of processing up to 12 samples simultaneously.

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NEW

Proteome Discoverer Software

Thermo Scientific™ Proteome Discoverer™ 1.4 software is the most comprehensive data analysis platform for qualitative and quantitative proteomics research. It includes a faster, multi-threaded SEQUEST™ and Library Searching tool for very fast data processing, and tools like Percolator and Byonic that maximize the information from MS/MS data.

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NEW

Protein Deconvolution Sofware

Thermo Scientific™ Protein Deconvolution 3.0 software provides accurate mass measurement and isoform quantification for intact proteins such as biotherapeutics. Now includes enhanced deconvolution algorithms, support for the Exactive Plus EMR system, and mirror plots for comparison of samples.

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NEW

Pinpoint Software

Thermo Scientific™ Pinpoint™ 1.4 software is a comprehensive targeted proteomics quantitation software supporting the analysis of proteins, peptides, and now glycoproteins (N- and O-linked) of standard and data independent analysis. Automated workflows facilitate all experimental aspects, from method development and acquisition to data verification and reporting.

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NEW

SIEVE Software

Thermo Scientific™ SIEVE™ 2.1 software automates differential analysis of metabolites, proteins, and peptides. SIEVE software includes a new advanced algorithm for small molecule peak detection that facilitates large-scale data reduction, reduces false positives, generates elemental composition information, and displays pathway mapping for metabolomics applications.

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mzCloud Advanced Mass Spectral Database

mzCloud is a new generation of HR/AM fragmentation library. Building a comprehensive and structurally diverse spectral library requires a collective approach, with an open community of scientific and industrial partners who voluntarily provide MSn spectral trees which, through a web-based interface, can be searched without restriction. Thermo Fisher Scientific is proud to contribute HR/AM Orbitrap data to mzCloud.

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TMT10plex Labeling Reagents

Thermo Scientific™ TMT10plex™ Labeling Reagents enable up to ten different peptide samples prepared from cells or tissues to be labeled in parallel and then combined for tandem MS analysis. The high-resolution MS/MS spectrum generated is used to measure relative protein expression levels.

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Pierce HeLa Protein Digest Standard

The Thermo Scientific™ Pierce™ HeLa Protein Digest Standard is a lyophilized tryptic peptide mixture that can be used as a quality control standard for LC separation, MS method development and MS performance benchmarking. It is specially formulated for LC-MS experiments and does not contain salts or detergents.

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Pierce Trypsin Protease, MS Grade

The ready-to-use liquid Thermo Scientific™ Pierce™ Trypsin Protease is a highly purified porcine trypsin that has been TPCK-treated to eliminate chymotryptic activity and methylated to improve stability during protein digestion.

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Pierce LysN Protease, MS Grade

Thermo Scientific™ Pierce™ LysN Protease is a MS-grade zinc metalloprotease that cleaves at the NH2-terminus of lysines, generating longer peptides than trypsin. Pierce LysN Protease is effective over broad temperature range and denaturing conditions, making it ideal for shotgun proteomics experiments.

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Fisher Chemical Specialized LC-MS Mobile Phase Blends

Fisher Chemical™ specialized solvent blends are developed for use in LC-MS, ideal for cutting-edge applications such as proteomics, metabolomics, clinical research, and drug discovery. Blends are function-tested and optimized for minimal impurities and interference-free baselines, thus maximizing performance in high-resolution and high-sensitivity LC-MS analysis.

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Fisher Chemical Improved Quality on Methylene Chloride

Through a Quality by Design approach, Optima™ and GC Resolve™ Methylene Chloride has new innovative packing, along with improved specifications based on 1000:1 concentration that will hold months after storage to ensure an interference-free baseline proven by GC-ECD, GC-FID and GC-MS.

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Fisher Chemical Solvents Specified for UHPLC-MS & UHPLC-UV

Last year, Fisher Chemical™ unveiled Optima LC-MS™ specified for UHPLC-UV. This year, a new line of Optima Acetonitrile, Methanol, and Water will be qualified for UHPLC-MS. Customers are ensured increased sensitivity, low background levels, and low metal ion content which minimizes adduct formation when running their UHPLC-MS applications.

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NEW

Virtuoso Vial Identification System

The Thermo Scientific™ Virtuoso™ Vial Identification System imprints customizable information DIRECTLY onto Thermo Scientific vials. The system provides an error-free solution to vial labeling, increased productivity and data quality with reliable vial identification.

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NEW

GlycanPac AXR-1 columns

Thermo Scientific™ GlycanPac™ AXR-1 columns enable industry-leading analysis of biologically important glycans. Their innovative mixed-mode column technology separates glycans based on charge, isomeric structure, and size. Available in multiple HPLC and UHPLC formats, they offer mass spectrometric detection of both labelled and native glycans.

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SOLAµ SPE Plates

Thermo Scientific™ SOLAµ™ plates are designed for bioanalytical and clinical research analysts who consistently require cleaner highly reproducible and robust sample extraction at very low sample volumes. Our award winning fritless SPE technology removes variability and optimizes your high throughput laboratory workflow.

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ProSwift RP-4H Capillary Monolithic HPLC Columns

Thermo Scientific™ ProSwift™ RP-4H Capillary Monolithic HPLC columns deliver fast, high-resolution separations of intact proteins and complex mixtures of large proteins. Their unique monolithic structure is designed to provide fast mass transfer, enhancing separation efficiency, delivering increased peak capacity and facilitating increased sample throughput.

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MSIA D.A.R.T.'S: Insulin, Streptavidin, and Protein A/G

Affinity purification using Thermo Scientific™ MSIA Disposable Automation Research tips (D.A.R.T.'S™) is central to the MSIA workflow. MSIA D.A.R.T.'S use a proprietary microfluidic column (contained within a functional pipette tip) that is derivatized with specific capture reagents to enable sensitive, reproducible, and confident quantification of specific analytes by LC-MS.

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Seminar

Register for our lunchtime seminar to learn about the latest transformations in technologies and solutions from Thermo Fisher Scientific experts and invited fellow scientists.

Tuesday, October 7, 2014 | 13:00 —14:00 | Room C

Multiplexed quantitation: The need for more data to drive understanding of functional biology and disease
Novel DIA methods for pathway analysis
Speaker: Michael Blank, Thermo Fisher Scientific
TMT10 plex analysis of the N-terminome by TAILS in NFkbeta stimulation
Speaker: Chris Overall, Canada Research Chair, The University of British Columbia, CA

Online registration is now closed. Please visit us at Booths 16-18.


Resources

Deep proteome profiling using HR/AM Selected Ion Monitoring and Data Independent Acquisition on the Orbitrap Fusion Tribrid MS

Author: Claire Dauly

Site Specific Glycosylation of Serum Proteins in Cancer Diseases – From Discovery to Quantification

Author: Michaela Scigelova

New Weapons Against Pervasive Fish Fraud: Top Down Proteomics and a New High Throughput LC-MS Platform

Author: Daniel Lopez-Ferrer

The Separation and Identification of Glycans Using an Ultra High Resolution Column and an Ultra High Resolution Mass Spectrometer

Author: Julian Saba

A Complete Workflow for Achieving High Accuracy Multiplexed N-Terminomics Data Using TMT10plex

Author: Michael A Blank

Informatics Support for Isomeric Separation and the Structural Identification of Labeled N-Glycans from Proteins

Author: Julian Saba

An Automated Workflow Solution for Identification and Quantification of Proteomes

Author: Xiaoyue Jiang

Proteomics of the Aging Liver Mitochondria: a PTM Quantitation Study

Author: Madalina Oppermann

Site Specific Glycosylation of Serum Proteins in Cancer Diseases – From Discovery to Quantification –

Author: Michaela Scigelova

Profiling EGFR Kinase Inhibitor Resistance Pathways in Non-small Lung Cancer Cell Lines

Author: Ryan Bomgarden

Combining NeuCode with LysC and LysN Digestion for De Novo Sequencing Applications

Author: Robert Cunningham

Relative Quantitation of N-linked Glycans Using Carbonyl-Reactive Tandem Mass Tag Reagents

Author: Sergei Snovida

Enrichment of EGFR/PI3K/AKT/PTEN Proteins using Immunoprecipitation and Analysis with Mass Spectrometry-based Proteomics

Author: Kay Opperman

Quantitation of oxidative stress response proteins in primary cardiomyocytes using NeuCode SILAC

Author: Ryan Bomgarden

An Automated Quality Control Platform for nano LC-MS Based Proteomics (Oral)

Speaker: Daniel Lopez-Ferrer

Oral Presentations

4:30 p.m.

Analytical Performance of a Novel, Dopant-Free GC-APPI Source with Femtogram-Level Sensitivity for Quadrupole-Orbitrap GC/MS

Session: MOD pm: Photoionization Author: Amelia C. Peterson Location: Room 314-317
8:30 a.m.

Multi-Step Sequencing and Confident Identification of Native Protein Complexes with an Orbitrap Mass Spectrometer

Session: TOD am: Macromolecular Complexes: Characterization and Dissociation Author: Mikhail BelovLocation: Room 314-317
10:10 a.m.

Setting New Speed Records for Orbitrap Mass Spectrometry

Session: TOB am: Instrumentation and Methods: FT, Ion Traps and Hybrid Instruments Author: Alexander MakarovLocation: Room 307-308
2:50 p.m.

Targeted Metabolomics in Clinical Research Labs using LC-HRMS: Longitudinal Metabotype Determination for Individualized Biology in Healthy Volunteers

Session: TOG pm: Clinical Diagnostics Author: Favre AmélieLocation: Ballroom III
9:30 a.m.

Moore's Law and the Consequence of Technological Change

Session: WOC am: The Triple Quadrupole: 35 Years of Evolution and Application to Celebrate Chris Enke's 80th Birthday Author: Alan SchoenLocation: Room 309-310
9:30 a.m.

Tandem Mass-Spectrometry on Native Non-Reduced and Reduced Antibody-Drug Conjugates using an Orbitrap Mass Spectrometer Equipped with a High-Mass Quadrupole

Session: WOF am: Pharmacoproteomics and Toxicoproteomics for Drug Development Author: Andrey DyachenkoLocation: Ballroom II
10:10 a.m.

Full Structure Elucidation of Elapid Snake Venom Proteins Targeting the Acetylcholine Receptor using the Latest Quadrupole-Orbitrap Mass Spectrometer

Session: WOF am: Pharmacoproteomics and Toxicoproteomics for Drug Development Author: Martijn PinkseLocation: Ballroom II
3:30 p.m.

Direct Analysis of Crude Oil using Orbitrap Mass Spectrometry with Resolving Powers Above 1,000,000

Session: WOA pm: Energy, Petroleum, and Biofuels: Advances in MS Design and Informatics Author: Marcos N. EberlinLocation: Exhibit Hall AB
3:10 p.m.

Applications and Performance of the GC/Quadrupole-Orbitrap MS in Discovery Metabolomics

Session: ThOG pm: Metabolomics/Lipidomics: New MS Technologies and Applications Author: Allison BalloonLocation: Ballroom III