Register for our annual Users' Meeting and see how our mass spectrometry solutions – from HRAM Orbitrap™ systems to sensitive triple quads to powerful software – can help you be selective and rise above the noise. From leading edge biological research to translational medicine to applied markets, hear from renowned guest speakers during our plenary session, followed by four parallel tracks in omics research, pharma/biopharma, environmental analysis and food safety, and clinical research.
Sunday, June 3, 2018
Registration and Breakfast — 7:00 a.m. - 8:00 a.m.
Plenary Session — 8:00 a.m. - 9:30 a.m.
Breakout Sessions — 9:30 a.m. - 12:15 p.m.
Wyndham San Diego Bayside
Gary Patti, Ph.D., Associate Professor, Washington University
Alexander Leitner, Ph.D., Principle Investigator, ETH Zurich, Institute of Molecular Systems Biology
Confidently determining molecular structure is increasingly becoming routinely possible on a large scale using advanced Thermo Scientific™ Orbitrap™ mass spectrometry tools. Integrated solutions for structural analysis available now shift the research focus in many laboratories from sequence to structure accelerating insights into functional aspects of biological systems. Join us in this session where our expert speakers share the newest developments in HRAM Orbitrap technology with applications in integrated structural protein analysis, multiplexed proteome profiling, and structural elucidation for metabolomics.
Results of an International Ring Trial for the Biocrates AbsoluteIDQ p400HR Targeted Metabolomics Kit
Will Thompson, Assistant Research Professor, Duke University
Application of 213 nm UVPD to the Characterization of Complex Intact Proteomes
Luca Fornelli, Postdoctoral Fellow, Northwestern University
Accelerating the Deep Annotation of Model Organism Metabolomes using a Thermo Scientific™ Orbitrap™ Tribrid™ Mass Spectrometer
Martin Jones, Postdoctoral Research Fellow, University of Birmingham
High Throughput Microflow LC-MS/MS: From Discovery Proteomics to Absolute Protein Quantitation
Matthew Foster, Assistant Professor, Duke University
Organelle Remodeling During Viral Infection
Ileana Cristea, Professor, Princeton University
Thermo Scientific™ mass spectrometry provides highly advanced instrumentation for the acquisition of rich datasets for characterization in all aspects of pharmaceutical and biopharmaceutical discovery and development. Mass spectrometry techniques are often used to precisely characterize the biotherapeutic protein in order to assess product quality. In this session, our expert speakers will share new developments in mass spectrometry technology and applications, including advanced fragmentation mechanisms and automated methods for data acquisition for complex structural elucidation from small molecules to native intact protein analysis.
Driving Drug Discovery and Development with Native MS of Membrane Proteins
Dame Carol Robinson, Professor, Oxford University
Keeping Pace with Cutting-edge Biotherapeutic Design: How Native Chromatography and Ultra-high Mass Range Enable Today's Intact Mass Analysis
Wendy Sandoval, Principal Scientific Manager in Research, Genentech
Validating Complex Mass Spectra of Proteins: A Step Forward to Top-down and Middle-down Mass Spectrometry for QC in Biopharma
Kristina Srzentić, Postdoctoral Research Associate, Northwestern University
Leveraging the MAM to Improve Biotherapeutic Characterization
Richard Rogers, Research Scientist, Just Biotherapeutics
Novel MSn Data Acquisition for Metabolite Identification
Jeff Gilbert, Research Leader, Dow Agrochemicals
The use of mass spectrometry in the applied markets continues to evolve, with routine targeted and non-targeted methods being developed for expanded lists of contaminants to newer areas like Foodomics and Exposomics seeing growth in the research communities. In this workshop, guest speakers will discuss their findings from regulated food and environmental laboratories, as well as from new research areas using cutting-edge high-resolution Orbitrap™ hybrid MS technologies.
The Analysis of Haloacetic Acids in Drinking Water using Ion Chromatography and a New Triple Quadrupole Mass Spectrometer
Neloni Wijeratne, Product Specialist, Thermo Fisher Scientific
Application of a HRMS Screening Method for Veterinary Drug Residues and Other Contaminants in Aquacultured Products
Sherri Turnipseed, Research Scientist, U.S. Food and Drug Administration
Integrated Workflow Solutions for Screening and Quantitation for Pesticides and Veterinary Products using QQQ and Orbitrap™ MS Systems
Ed George, Environmental & Food Safety Applications Manager, Thermo Fisher Scientific
Application of the Thermo Scientific™ Q Exactive™ Focus MS for the Identification and Quantification of Substances Migrating from Food Contact Materials in the Context of European Regulations
Els van Hoeck, Senior Scientist, WIV-ISP
Analysis of Food Contact Materials using the Thermo Scientific™ GC-Orbitrap™ MS
Gyorgy Vas, Manager, Trace Organic Analytical Laboratory, Intertek Pharmaceutical Services
Mass spectrometry continues the march towards routine implementation in scalable healthcare possibilities. Mass spectrometry delivers critical data needed in a variety of clinical research studies to characterize population segments, phenotypical disease state, progression, and response to research treatments. Through integrated research (genomics, proteomics and metabolomics), we are approaching an era where we can practically measure levels (or changes) of any known biological entity. In this session, our expert speakers will share how mass spectrometry has driven their clinical research to its current state of practical implementation, and now towards new paradigms in precision health and medicine.
A New Precision Medicine Center: Translating Biological Investigations into Healthcare Possibilities
Emily Chen, Senior Director, Precision Medicine Science Center, Thermo Fisher Scientific
PaperSpray MS for Clinical Research Applications: Current Capabilities and Future Possibilities
Nick Manicke, Assistant Professor, Indiana University Purdue University at Indianapolis (IUPUI)
Clinically Relevant Analytical Studies of Heart Disease
Qin Fu, Ph.D., Director of High-Throughput Laboratory, Advanced Clinical Biosystems Research Institute, Cedars-Sinai
Oncology Protein Markers in the CLIA Lab Environment
Maryann Vogelsang, Clinical Director, NantOmics, LLC
Targeted Quantitation to Study Cancer Biology and Assay Translation from Model Systems to Measurement of Clinical Trial Correlates (RUO)
John Koomen, Associate Member, Moffitt Cancer Center
Attend our Breakfast Workshops to learn from fellow scientists and Thermo Fisher Scientific experts how mass spectrometry innovations can help you reduce ambiguity, improve your quantitative accuracy and precision, more confidently profile and classify your complex samples, and correctly identify more metabolites, impurities, or contaminants.
To understand protein function and mechanism of action, it is essential to determine protein complex assembly and structure. Thermo Fisher Scientific leads the way in accelerating protein structure-function studies with its Integrative Structural Biology solutions. Thermo Scientific™ Orbitrap-based mass spectrometers enable characterization of complex and dynamic structure-function relationships. In this workshop, our expert speakers will share new approaches for structural proteomics workflows for crosslinking and native MS.
Defining Interacting Networks of Membrane Proteins, Lipids, Ligands and Drugs
Joseph Gault, Junior Research Fellow, University of Oxford
Developing Sulfoxide-containing MS-cleavable Cross-linkers for Interactomics and Structural Biology
Lan Huang, Professor , University of California, Irvine
Determining the chemical structure of the majority of compounds "identified" in a typical untargeted analysis remains a stubborn challenge and a persistent logjam, holding up progress in many fields including metabolomics, metabolism studies, forensics, contaminant analysis, and E&L identification. In this workshop, we will describe a fundamental new approach to untargeted small molecule analysis involving optimized systems, powerful new data acquisition strategies, and an arsenal of new software tools to translate high quality Orbitrap mass spectra into more, confidently-assigned small molecule structures.
Novel Approaches for Improved Small Molecule Identification and Characterization using Thermo Scientific™ Orbitrap™ Tribrid™ Mass Spectrometer
Seema Sharma, Product Manager, Thermo Fisher Scientific
Enhanced Metabolite Identification using Thermo Scientific™ Orbitrap™ Tribrid™ Mass Spectrometer
Shuguang Ma, Senior Scientist, Genentech
Orbitrap-based LC-MS is an invaluable tool to reveal important structural information about complex biologics, including antibodies, ADCs, and other emerging modalities. New analytical methods couple novel chromatographic separations with advanced mass spec methods to yield impressive new levels of insight. In this workshop, we will highlight the latest instrumentation and software for protein therapeutic characterization.
Combination of Native and Middle-down Mass Spectrometry for In-depth Characterization of a Site-specific Antibody-drug Conjugate
Oscar Hernandez Alba, Post-doctoral Research Associate. BioOrganic Mass Spectrometry Laboratory, University of Strasbourg
Navigating Complexity of Intact Next Generation Biotherapeutics using Native Separations Coupled to Ultra High Mass Orbitrap™ MS
Aaron Bailey, Product Marketing Manager, Thermo Fisher Scientific
A comprehensive view of human health must include the food we eat and the environment we inhabit. In this workshop, we will explore the use of Thermo Scientific™ Orbitrap™ mass spectrometry to define and analyze allergens in our food and to comprehensively characterize persistent organic pollutants (POPs) and other toxins in our personal environment. Presenters will share advanced strategies and tools for detailed, sensitive identification and quantitative analysis of these important compounds.
Selecting Peptide Targets for Allergen Detection and Quantification using an Orbitrap™ MS
Phil Johnson, Assistant Professor, Department of Food Science and Technology, FARRP, University of Nebraska-Lincoln
Exposomics and Environmental Research into Dust Particles and the Effects on Human Health using the Thermo Scientific™ Orbitrap™ Fusion™ MS
Lee Ferguson, Associate Professor, Department of Civil & Environmental Engineering, Duke University
Thermo Scientific™ Tandem Mass Tags (TMT) reagents enable deep, quantitative proteome profiling with the added benefit of a 10X gain in sample throughput. Multiplexed isobaric tags can be used for a wide variety of samples providing exceptional analytical depth, high throughput, reproducibility, with few missing quantitative values. In this workshop, our expert speakers will share the latest advances and newest technologies in multiplexing workflows, including a new TMT standard and software that can be used to rigorously benchmark Thermo Scientific™ Orbitrap™ MS system performance.
Multi-proteomic Approaches to Study the Epithelial to Mesenchymal Transition
Noah Dephoure, Assistant Professor, Weill Cornell Medical College
TKO: A Proteomics Standard to Benchmark Instrument Performance and Diagnose Ion Interference in Isobaric Labeling Experiments
Joao Paulo, Instructor, Harvard Medical School
Developing accurate and precise quantitative assays can be challenging and time consuming. The most challenging target compounds and matrices often require dedicated sample preparation and enrichment to drive assay selectivity. To fully complement these high-performance workflows, having the highest levels of LC-MS detection and selectivity is often a major advantage in meeting assay demands. Our expert panel will highlight the power of selectivity for both triple quadrupole and Thermo Scientific™ Q Exactive™ Orbitrap MS applications to meet the needs of the most demanding applications.
Increasing Sensitivity and Reproducibility in Protein Receptor Synthesis Measurements in Human Serum Utilizing Immunoaffinity Nanoflow LC/MS/MS
Jay S. Johnson, LC-MS Scientist, BioMedicine Design, Pfizer Worldwide
Novel Analytical Approaches for the Quantitation of Oligonucleotides - Combining LC-HRMS and LC-FL Based Techniques
Alexander Behling, Senior Scientist, PPD Laboratories Biomarker Lab
Unknown metabolomics provides a comprehensive readout of biochemical phenotype. Yet this readout is meaningless without confident and well-defined compound identification. Taking a novel approach that utilizes a Thermo Scientific™ Orbitrap™ Tribrid™ mass spectrometer renders more unique compounds with deeper structural characterization using MSn fragmentation for confident annotations of unknowns. This analysis approach in combination with Thermo Scientific™ Compound Discoverer™ software and Thermo Scientific™ LipidSearch™ software gives you access to your inner chemist to confidently know more unknowns.
The Impact of Diet on the Insect Lipidome Analyzed by High-Resolution LC/MSn Orbitrap™ Mass Spectrometry
Daniel Gachotte, Research Scientist, Dow AgroSciences
Unknown Identification Has Never Had It So Good. Thermo Scientific™ Compound Discoverer™ Software Takes Unknown Metabolomics to a Whole New Level with Newly Integrated Annotation Tools.
Ralf Tautenhahn, Platform Manager Metabolomics Software, Thermo Fisher Scientific
Saturday, June 2, 2018
Registration and Breakfast — 8:30 a.m. - 9:00 a.m.
Wyndham San Diego Bayside
Discover powerful new features in Compound Discoverer 3.0 software and get training on advanced workflows. We are pleased to have distinguished guest speakers who will discuss their experiences with Compound Discoverer software.
|8:30 a.m.||Registration & Continental Breakfast|
|9:00 a.m.||Welcome||Tim Stratton, Product Manager, Thermo Fisher Scientific|
|9:15 a.m.||Compound Discoverer 3.0 Software: Overview of New Features I||Ralf Tautenhahn, Product Manager, Thermo Fisher Scientific|
|10:30 a.m.||Compound Discoverer 3.0 Software: Overview of New Features II||Ralf Tautenhahn, Product Manager, Thermo Fisher Scientific|
|11:30 a.m.||Optimized Chemical Coverage and Data Quality for Non-Targeted Screening||Ann M. Knolhoff, Research Chemist, FDA|
|1:00 p.m.||Metabolomics Workflows with Examples||Ralf Tautenhahn, Product Manager, Thermo Fisher Scientific|
|2:00 p.m.||Thermo Scientific™ Compound Discoverer™ 3.0 Software Accelerates Research in Synthetic Biology by Enabling Analysis of Stable Isotope Labeling (SIL) Data to Probe Heterologous Pathways||Juan Moises Sanchez, Associate Scientist, Intrexon|
|2:45 p.m.||Thermo Scientific™ Compound Discoverer™ Software and Metabolite Identification in Drug Discovery||Ron Aoyama, Senior Research Scientist, Gilead Sciences|
|3:15 p.m.||E&L and Metabolism Workflows with Examples||Tim Stratton, Product Manager, Thermo Fisher Scientific|
|4:15 p.m.||Q&A Session and Wrap-up||Ralf Tautenhahn, Product Manager, Thermo Fisher Scientific|
A great opportunity to learn how to create nodes, meet our software developers, and get your most vexing questions answered.
|8:30 a.m.||Registration & Continental Breakfast|
|9:00 a.m.||Node Development Overview I||Tim Nulpa, Software Developer, Thermo Fisher Scientific|
|10:30 a.m.||Node Development Overview II||Tim Nulpa, Software Developer, Thermo Fisher Scientific|
|1:00 p.m.||Hands-on Examples||Tim Nulpa, Software Developer, Thermo Fisher Scientific|
|2:45 p.m.||Hands-on Examples||Tim Nulpa, Software Developer, Thermo Fisher Scientific|
|4:00 p.m.||Q&A Session and Wrap-up Proteome Discoverer Software Questions / Compound Discoverer Software Questions||Tim Nulpa, Torsten Ueckert, Sebastian Kusch, Kai Fritzemeier, Software Developers, Thermo Fisher Scientific|
Pre-requisites for attending the node development workshop
Note: Because the node workshop is one day only, it is best that you are currently attempting to create a node using the node SDK before the attending. Our software developers will be present so it would be most effective if you bring your questions.
*C# programming experience required.
Excited by the power and potential of your Thermo Scientific™ Orbitrap™-based mass spectrometer? Join us for a first-hand demonstration of the new features in the Tune, Method Editor, Thermo Scientific™ Xcalibur™, and FreeStyle™ applications. From small molecules to large, receive training on standard, built-in workflows and advanced method execution by using XML and iAPI-based technologies.
|8:30 a.m.||Registration & Continental Breakfast|
|9:00 a.m.||Welcome and Introduction||Shannon Eliuk, Senior Platform Manager, Instrument Control Software, Thermo Fisher Scientific|
|9:05 a.m.||iAPI Development and XML Modification Overview: Thermo Scientific™ Tribrid™ and Exactive™ MS Series||Derek Bailey, Senior Software Scientist, Thermo Fisher Scientific|
|9:35 a.m.||All Online: Peptide Matching and Statistical Inference on a Thermo Scientific™ Ordbitrap Fusion™ Lumos™ Mass Spectrometer||Devin Schweppe, Postdoctoral Fellow, Harvard Medical School|
|10:15 a.m.||Global Targeting with MaxQuant Live||Christoph Wichmann, Postdoctoral Researcher, Max Planck Institute of Biochemistry|
|10:40 a.m.||iAPI Development: Examples and FAQ||Derek Bailey, Senior Software Scientist, Thermo Fisher Scientific|
|11:35 a.m.||Application of XMLMethodChanger for Automated Multi-modal Gas-phase Protein Fragmentation||Pavel Shliaha, Postdoctoral Researcher, University of Southern Denmark|
|1:00 p.m.||Thermo Scientific™ Q Exactive™ MS Series: Overview and New Features||Markus Kellmann, Product Manager, Thermo Fisher Scientific|
|1:35 p.m.||Thermo Scientific™ Orbitrap™ Tribrid™ MS Series: Overview and New Features||Shannon Eliuk, Senior Platform Manager, Instrument Control Software, Thermo Fisher Scientific|
|2:45 p.m.||Detection of Hundreds of Environmental Stress Protein Biomarkers using Targeted Metaproteomics in the Oceans||Mak Saito, Senior Scientist, Woods Hole Oceanographic Institution|
|3:10 p.m.||Xcalibur Application: Overview and New Features||Ryo Komatsuzaki, Senior Manager, Product Management, Thermo Fisher Scientific|
|3:40 p.m.||FreeStyle Application: Overview and New Features||Julie Horner, Product Manager, Thermo Fisher Scientific|
|4:30 p.m.||Q&A Session and Wrap-Up||Shannon Eliuk, Senior Platform Manager, Instrument Control Software, Thermo Fisher Scientific|
Note: You do not need to be registered for ASMS to attend these events.
Grape Street Pier
1800 North Harbor Drive
San Diego, CA 92101
Spend the afternoon cruising the beautiful San Diego bay aboard the Inspiration Hornblower, the largest charter yacht in Southern California. Enjoy a buffet meal, refreshments, perfect weather, and the spectacular backdrop of "America's Finest City." With three spacious decks, there is plenty of room to mingle and socialize.
The departure pier is a short walk from the Wyndham Bayside.
|Sunday, June 3||7:45 p.m. - 9:30 p.m.|
|Monday, June 4||9:00 p.m. - 5:00 p.m.|
|Tuesday, June 5||9:00 p.m. - 5:00 p.m.|
|Wednesday, June 6||9:00 p.m. - 5:00 p.m.|
|Thursday, June 7||9:00 p.m. - 2:30 p.m.|
Connect with us in our hospitality suite featuring MS technologies and software solutions.
Monday, June 4 - Wednesday, June 6
Hilton San Diego Bayfront
1 Park Boulevard
Sapphire Ballroom ABEF
66th ASMS Conference on Mass Spectrometry and Allied Topics
San Diego Convention Center
111 W. Harbor Dr.
San Diego, CA 92101
Sunday, June 3 - Thursday, June 7