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Ask the Expert — an educational and interactive series for lab professionals by Thermo Fisher Scientific, the world leader in serving science.

The scientific community, with expertise in discoveries, breakthrough and innovations, is being pushed to deal with challenges daily. Our best efforts always come from collaboration and sharing of information and expertise. We hear that you need to cut down your hours in the lab on analysis and get the results fast. Yes, we know that as lab professionals, you face a multitude of challenges including productivity, flexibility, sensitivity, reproducibility, ease of operation and compliance.

With this in mind, we bring together some of the leading experts we know, to hear from you and help you by sharing more to overcome your lab challenges. “Ask the Expert” is a series of 30-minute webinars and 30-minute live Q&A sessions that will address your concerns in the laboratory. Whether it is about chromatography, mass spectrometry or trace elemental analysis, this group will sound off regularly on questions about overcoming obstacles, weigh in on latest technology and even what books sit on their nightstands—and they will share responses in this virtual town square.


Wednesday, 29 July 2020

12.30 – 1.30pm (New Delhi)
2 – 3pm (Bangkok, Jakarta)
3 – 4pm (Singapore, Kuala Lumpur, Taipei)
4 – 5pm (Tokyo, Seoul)
5 - 6pm (Canberra)
7 - 8pm (Christchurch)

Speaker
Dr. Cook
Thermo Fisher Scientific



Updating your Peptide Mapping and Glycan analysis for Therapeutic proteins

Peptide mapping is a fundamental workflow that is required to ensure that the bio-therapeutics structural integrity is maintained at all stages of the drug development pipeline. This is required for the maintenance of drug efficacy and patient safety.

This webcast details how new technologies can deliver peptide mapping which is:

  • • Fast, Reproducible and precise
  • • Easy for untrained operators and automatable
  • • Provides high quality results with low Post Translational Modifications (PTMs)

Glycan Analysis which is:

  • • Driven from peptide mapping
  • • At the intact and middle up level
  • • Released and labeled Glycans using innovative column selectivity’s for different sample types

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Thursday, 13 August 2020

12.30 – 1.30pm (New Delhi)
2 – 3pm (Bangkok, Jakarta)
3 – 4pm (Singapore, Kuala Lumpur, Taipei)
4 – 5pm (Tokyo, Seoul)
5 - 6pm (Canberra)
7 - 8pm (Christchurch)

Speaker
Mario Tuthorn
Product Marketing Manager GIRMS &B OEA
Thermo Fisher Scientific



Isotope Fingerprints for Environmental Investigations

The natural and synthetic materials have a fingerprint, a unique chemical signature that allows them to be identified and differentiated from one another. Consequently, we are able to interrogate samples, chemically, to determine where they came from, allowing measures to be developed and executed to reduce and remove environmental pollution.

In this presentation we explain how stable isotope fingerprints of carbon, nitrogen, sulphur, oxygen and hydrogen are used to identify the origin of air, soil and water pollution. Data are shown that illustrate how isotope fingerprints offer conclusive answers on questions associated with where pollution came from.

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Panelists: Darren Barrington-Light Senior Product Marketing Manager Enterprise Chromatography Data Systems Thermo Fisher Scientific Holger Franz Manager, HPLC Product Management Thermo Fisher Scientific

Simple to the CORE – The new Thermo Scientific Vanquish Core HPLC system

Built upon the innovative Vanquish platform, the new Vanquish Core HPLC system provides exceptional analytical precision, detector sensitivity, and operational simplicity to enable unprecedented reliability and robustness. Designed specifically for routine analysis laboratories. Addressing the benefits of our exceptional technology.

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Questions and Answers

In the spirit of collaboration, sharing of information and expertise, these are some of the questions that were raised in the session and henceforth, responses from our Experts. If you have more questions with regard to the topic, please fill in your enquiry here.

Event: Simple to the CORE – The new Thermo Scientific Vanquish Core HPLC system

Question Answers
How can this Technology be more easy for students? Chromeleon CDS can support academic learning through streamlined workflows using eWorkflows. This simplifies sequence setup and ensures correct methods and reports are used for each anaylsis. With Chromeleon 7.3 CDS, students can install it on their own PCs, get a 60 day temporary license, take their data on e.g. a thumb drive in CMBX format and analyse this data remotely, offline.
How fast does HPLC show the result when having mixture of two different molecules in the solution? How about with both having different solubility in the solvent? The time it takes to separate two analytes depends on the nature of the compounds and the combination of mobile and stationary phase. If only simple separation is required, it is possible to complete it in less than a minute. Separations of very similar compounds might not even be completed after 30 minutes or more.
What happens if my sample solvent is stronger or weaker than my mobile phase? Injecting a weaker-eluting solvent, for instance a water-rich solvent, in reversed phase HPLC typically has a positive effect. Analytes are enriched at the head of the column until the eluting takes effect. This typically leads to narrower peaks and therefore better peak resolution. With a stronger eluting sample solvent, for instance methanol for RP chromatography, early eluting peaks might show a fronting. The extent of the effect depends on the injection volume and the column volume. It can also play a role in method transfer. With Vanquish Core we published an application note that helps with how to deal with this.
How long will HPLC systems be supported and tests ranges extended in the era of Tandem Mass Spec? A great thing about Vanquish Core is the flexibility of the platform. One can easily combine different types of pumps and add-ons; for instance column switching valves. Vanquish Core will therefore also be able to support tandem mass spec analyses. The software infrastructure to support this will be available in the near future. With respect to the time, Vanquish Core is technically supported with spares and wears: The product has just been launched and will remain on the market for several years. From the time the product is no longer manufactured, Thermo Fisher Scientific guarantees at least 7 years of full product support.
Is Vanquish core suitable for small labs?

Is there a requirement of minimum samples analyzed each day to have optimum benefit from the system?

Can it be controlled from desktop PC like CM7 software?
Chromeleon 7.3 CDS is the recommended software for the Vanquish Core HPLC. It supports working locally on a single PC and also remote working via a network so the instrument can be controlled and monitored from an office along with data processing and reporting
How do you check for reproducibility and robustness? The Chromeleon ICH Method Validation Extension Pack provides everything you need to perform reproducibility and robustness testing with predefined report templates to automate reporting.
Can you explain about UHPLC?  Is it robust and reliable? UHPLC was commercialized in 2004. Since then, we as a manufacturer have seen an initial adoption of the technology in research and development laboratories. Meanwhile, the pressure capabilities of most routine HPLC instruments have increased to at least 600 bar (8700 psi). A typical approach is to recommend 80% of the pressure capabilities of an HPLC instrument as maximum pressure for permanent use. With Vanquish Core, 700 bar therefore provides you with 480 bar (7000 psi) permanent pressure. The instrument is in fact designed to support this very well. UHPLC columns are based on the use of sub-2 µm particles. One of the issues with that is that the interstitual spaces are smaller than for conventional HPLC columns. These columns therefore require suitable filtering of solvents and samples to prevent clogging. My personal opinion is that many old HPLC applications can run faster using solid core particles of for instance 2.5 - 3.0 µm particle size, for instance in 3 mm i.d. columns. It is a great compromise for routine, providing much better performance than 5 µm particles in 4.6 mm i.d. columns and are not as likely to clog as sub-2 µm particle columns.
Is there a difference if I run a similar sample using the same column and same method on UHPLC as to compare to the same on HPLC? What are the differences? Yes, there is. UHPLC columns use sub-2 µm particles that are more efficient than conventional HPLC columns, filled for instance with 5 µm particles. With UHPLC columns it is possible to achieve the same level of separation in a shorter time. A side effect is higher operating pressure, therefore the instrument must be suitable for these higher pressures. Another side effect can be that the interstitual volume between the particles of the column s smaller compared to HPLC columns. To avoid clogging, a suitable solvent and sample filtering is important or robust operation.
Compared to the previous HPLC model, what is new technology introduced in the Vanquish CORE system? Any improvement done on the solvent monitoring system? The Vanquish Core webinar (available here) offered a good overview on the long list of new features of the Vanquish Core system. The solvent level monitoring system is introduced with Vanquish Core, and is compatible with the rest of the Vanquish platforms.
How is the performance of the Vanquish Core HPLC system comparable to that of  Water;s or Shimadzu's Pinnacle series systems? Vanquish Core is the most modern routine HPLC instrument. It offers a higher level of performance and dependability than any other HPLC instrument. Some highlights are the superior hardware design, diagnostics, solvent level monitoring, method transfer features and the flexibility of the instrument. Our testers confirmed that Vanquish Core allows them to do their job more reliable and more efficient than with previous, other vendor instruments.
What can be done if the Vanquish Core system encounters an error? The instrument is designed in an intuitive way. It provides tools supporting novice users. In case of error or questions, we have a very strong team of supporters and engineers to help.
How to get good resolution and sensitivity for the separation using buffer in mobile phase system? This is really about how to design a separation. I can recommend the book "Practical HPLC Method Development" from Kirkland, Snyder and Glajch that provides a great overview over all factors that play a role.
How many compounds can be analyzed efficiently in one run? This very much depends on the nature of the column and the separation setup. Typical HPLC  runs separate up to 10-15 compounds. Examples can be found here: https://appslab.thermofisher.com/
Panelists: Matthew Cassap Product Marketing Specialist TEA Thermo Fisher Scientific Sebastian Weyermann Product Manager ICP-OES Thermo Fisher Scientific Nora Bartsch Product Specialist ICP-OES Thermo Fisher Scientific

Perform Like a Pro: Fast ICP-OES Analysis with the Latest Advances

This webcast will focus on the most recent advances in Inductively coupled plasma-optical emission spectroscopy (ICP-OES), address challenges such as ability to analyze high matrix samples restricted to radial only instruments, balance between speed and sensitivity that are faced by analytical chemists and ensure that these challenges are no longer barriers to your trace elemental analysis.

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Panelist: Christopher Pohl Vice President, Chromatography Chemistry Thermo Fisher Scientific

Column Selection and Troubleshooting in Ion Chromatography

With so many different ion chromatography columns, it can be confusing to choose the right column. Join Christopher Pohl, Vice President, Chromatography Chemistry in the Chromatography & Mass Spectrometry Division of Thermo Fisher Scientific, as he reviews basic column options, the use of virtual column as a means of selecting a column, optimum column selection depending upon sample characteristics and some of the newest columns.

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Panelists: Daniela Cavagnino Product Marketing Manager, GC/GCMS Thermo Fisher Scientific Cristina Jacob Product Marketing Manager, LSMS Thermo Fisher Scientific Richard Fussell Global Marketing Manager, Food and Beverage Thermo Fisher Scientific

Automated online µSPE clean-up to improve efficiency, robustness and productivity in LC- and GC-MS/MS analysis of pesticide residues

The trend for multi-residue pesticide analysis is towards faster, simpler, more generic methods of extraction with minimal, if any, clean-up to facilitate higher sample throughput. This webinar will describe a new automated and optimized online miniaturized cartridge clean-up providing more effective clean-up of QuEChERS extracts to overcome the analytical challenges faced by laboratories undertaking pesticides residues analysis.


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Panelists: Shanhua Lin, Ph.D. Director, Research and Development Chromatography Columns and Consumables Thermo Fisher Scientific

Advances in Column Technology and Universal Separation Platform for Analysis of Monoclonal Antibodies (mAbs)

Biopharmaceuticals such as monoclonal antibodies are complex and consequently the array of tools and techniques required to fully characterize them is extensive. The webinar offer comprehensive overview of the advanced column technology in biopharmaceutical characterization developed by Thermo Fisher Scientific: including size exclusion, ion-exchange, hydrophobic interaction, and reversed phase chromatography.


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Online Learning

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Panelists: Shanhua Lin, Ph.D. Director, Research and Development Chromatography Columns and Consumables Thermo Fisher Scientific

Advances in Column Technology and Universal Separation Platform for Analysis of Monoclonal Antibodies (mAbs)

Biopharmaceuticals such as monoclonal antibodies are complex and consequently the array of tools and techniques required to fully characterize them is extensive. The webinar offer comprehensive overview of the advanced column technology in biopharmaceutical characterization developed by Thermo Fisher Scientific: including size exclusion, ion-exchange, hydrophobic interaction, and reversed phase chromatography.

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Panelists: Daniela Cavagnino Product Marketing Manager, GC/GCMS Thermo Fisher Scientific Cristina Jacob Product Marketing Manager, LSMS Thermo Fisher Scientific Richard Fussell Global Marketing Manager, Food and Beverage Thermo Fisher Scientific

Automated online µSPE clean-up to improve efficiency, robustness and productivity in LC- and GC-MS/MS analysis of pesticide residues

The trend for multi-residue pesticide analysis is towards faster, simpler, more generic methods of extraction with minimal, if any, clean-up to facilitate higher sample throughput. This webinar will describe a new automated and optimized online miniaturized cartridge clean-up providing more effective clean-up of QuEChERS extracts to overcome the analytical challenges faced by laboratories undertaking pesticides residues analysis.

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Speaker: 이정우 Column & Consumable Manager Thermo Fisher Scientific

극성물질 분석을 위한 HPLC column selection

HPLC 분석을 위한 효과적인 분석 방법과 극성 물질 분석을 위한 column selection 소개.

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Panelist: Christopher Pohl Vice President, Chromatography Chemistry Thermo Fisher Scientific

Column Selection and Troubleshooting in Ion Chromatography

With so many different ion chromatography columns, it can be confusing to choose the right column. Join Christopher Pohl, Vice President, Chromatography Chemistry in the Chromatography & Mass Spectrometry Division of Thermo Fisher Scientific, as he reviews basic column options, the use of virtual column as a means of selecting a column, optimum column selection depending upon sample characteristics and some of the newest columns.

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Speaker: Dr. Ranjan Mitra Head-Analytical Development Dabur Research Centre, India

Food & Beverage Fraud Identification by IRMS

Food & beverage products have a fingerprint, a unique chemical signature. To visualize this fingerprint, Isotope Ratio Mass Spectrometry can be used.

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Speaker: 洪晟瀚博士 Dr. Ethan Hung 卓越技術中心 應用科學家 Application Scientist,COE 台灣賽默飛世爾科技 Thermo Fisher Scientific

同位素比值質譜儀在食品安全的應用

本次網路研討會將介紹賽默飛世爾科技的同位素比值質譜儀及應用實例。

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Speaker: James Hannan Application Specialist Discrete Industrial Analyzers Thermo Fisher Scientific, Hemel Hempstead, UK

Rapid Photometric Detection for Food & Beverage Applications

Our DIA Specialist also discusses how these systems are an efficient alternative to traditional flow analyzers and how the unique low volume cuvette design produces cost savings in reagents and waste.

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Speaker: Dr. Dasharath P. Oulkar Manager FSSAI-Thermo Fisher Scientific Food Safety Solution Center, Ghaziabad Thermo Fisher Scientific India

Different Sample Preparation Approaches for Food Safety Applications

Join us for a webinar to learn about modern sample preparation approaches to handle simple as well as difficult/ complex matrices in food and beverage samples with a simplified approach by utilizing advanced analytical tools

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Speaker: James Hannan Application Specialist Discrete Industrial Analyzers Thermo Fisher Scientific, Hemel Hempstead, UK"

Rapid Photometric Detection for Environmental Applications

Our DIA Specialist will also discuss how this technique is an efficient alternative to traditional flow analyzers and how the unique low volume cuvette design produces cost savings in reagents and waste.

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Speakers: Wai-Chi Man Ion Chromatography - Technical Specialist Thermo Fisher Scientific George Renney Field Application Specialist Thermo Fisher Scientific

Fast, Robust and Sensitive Analysis of Haloacetic Acids (HAAs) using IC-MS/MS

In this on-demand webinar, the presenters will share a new HAA application using innovations in ion chromatography coupled to triple quadrupole mass spectrometry and will detail the flexibility and time-savings of an optimized IC-MS setup together with its ability to offer sensitive, robust & reproducible results.

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Speaker: Maciej Bromirski Senior Global Product Marketing Manager Thermo Fisher Scientific

Introduction to Orbitrap Exploris 480 MS – New Platform, New Technology, Novel Capabilities

Attend this on-demand webinar to learn about proteome profiling with next generation FAIMS ion mobility technology, quantitative protein analysis and protein characterization for translational research.

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Speaker: Dr. Pierre Thibault Professor Department of Chemistry, Faculty of Arts and Sciences Institute for Research in Immunology and Cancer (IRIC)

Proteomic Music from Biological Noise

Dr. Pierre Thibault presented a simple, new step to their existing workflow with the addition of a novel gas phase ion fractionation device to increase proteome coverage and confidence in global proteome profiling. This study will highlight the advantages of the Thermo Scientific FAIMS Pro device in quantitative proteomics using SILAC and TMT labelling to improve the accuracy, precision, and comprehensiveness of quantitative measurements.

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Speaker: Scott M. Peterman Ph. D Sr. Global Marketing Manager Thermo Fisher Scientific

How to Maximize Label-Free Quantitation (LFQ) on a Tribrid Mass Spectrometer

This webinar will present the top 5 features associated with the Orbitrap Tribrid MS and demonstrate the importance of high resolution, stable mass measurement accuracy, and the introduction of the FAIMS Pro interface for balancing increased proteome coverage, maintaining relative quantitation, and maximizing throughput.

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Speaker: Amanda Souza M.S Metabolomics Program Manager Thermo Fisher Scientific

Escape the Metabolomics Identity Crisis with Intelligence Driven Mass Spectrometry

High-resolution accurate-mass spectrometry delivers informative analytical measurements providing biological insight. Yet, converting mass spectra into confidently annotated compounds is a difficult process due to the complexity of small molecules hindering confident biological interpretation. In this webinar, you’ll be introduced to new workflow strategies for data acquisition and analysis that have been developed for metabolomics applications.

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Speaker: Steven Gygi Professor Harvard University

Instant Answer: All the Data in Half the Time Using a Real-time Database Search for Isobaric Labeling Studies

This webinar presents strategies that combine next generation technologies in multiplexing chemistry, hardware and software for increased quantitative performance and throughput efficiency on Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer.

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Speakers: Liu Head of Mass Spectrometry Proteomics Core Jesper Olsen Vice Director Novo Nordisk Foundation Center Reid Townsend Professor Washington University Lan Huang Professor of Physiology & Biophysics University of California Nick Seyfried Associate Professor Emory University School of Medicine Steve Carr Director of Proteomics Broad Institute of MIT Roman Fischer Principle Investigator University of Oxford

Mass Spectrometry in Proteomics

Join thought leaders and peers at the proteomicsNOW virtual conference to learn about the latest advances in proteomics, share best practices, and explore new technologies and techniques designed to help improve your research results.

This event highlights recent developments in proteomics through live webinars, lightning talks, poster sessions, and panel discussions. Since we know how hard it is to set aside long periods of time to watch groundbreaking scientific talks, the event is available on demand as well.

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講演者: 草川 佳久様 シミックファーマサイエンス株式会社 神戸ラボラトリー 事業推進室

GLP施設におけるLC-MSMSでのDI対応

GLP施設で利用されている機器については,スタンドアローン仕様で利用されているものが多く,電子データを生データとして使用されているLC-MS/MSを例としデータインティグリティ確保のための課題や,課題解決のためのChromeleon クロマトグラフィーデータシステムを利用した運用管理方法を紹介する 。

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Speaker: Neil Kelleher Director Northwestern University

Ultrahigh Performance for Resolving Proteoforms in Targeted and Discovery Modes

Laboratories who are looking to obtain rich information from proteoforms will benefit from this on-demand webinar about high quality datasets generated from the Thermo Scientific Orbitrap Eclipse Tribrid MS platform. The presented data will cover both denatured and native modes for the analysis of whole proteoforms and their complexes.

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Speaker: Ryan Kelly Ph.D Brigham Young University

One Cell at a Time: Single Cell Proteomics Becomes a Reality

In this webinar, Dr. Ryan Kelly will describe: nanoPOTS, a new sample processing platform to maximize sample recovery; miniaturization of LC separations; and latest-generation of MS instrumentation to provide the required sensitivity and throughput for effective analysis of such trace samples.

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Speaker: Jesper Olsen Professor University of Copenhagen

Achieve High Throughput LC-MS Screening while Maintaining Protein Depth and Quantitative Accuracy using an Intelligence-Driven MS and Differential Ion Mobility

In this on-demand webinar, learn about how the combination of the Thermo Scientific Orbitrap Exploris 480 mass spectrometer with the FAIMS Pro interface significantly increased proteome coverage when using single VCs and short LC gradients.

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Speaker: Dr. Ken Cook EU Bio-Separations Expert Thermo Fisher Scientific

Fast, reproducible biopharmaceutical charge variant profiling

In this webinar, learn about the newest addition in our comprehensive portfolio of products for bio separations.

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Speaker: Dr. Ken Cook EU Bio-Separations Expert Thermo Fisher Scientific

The Sweet Revolution in Glycan and Antibody Separations

We discuss the difficulties of characterize monoclonal antibodies and other similar biotherapeutics and also the current technologies used to maximize glycan separation capabilities and structural elucidation.

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발표자: 이정향 HPLC 와 LCMS의 Application Chemist Thermo Fisher Scientific

Innovation and profitability in routine HPLC - Why change?

실험실의 생산성 증대와 사용자 편의의 장비 운영요구와 더불어 수익성과 관련된 장비의 Return on investment 및 Total Cost of Ownership 향상이 중요시되고 있습니다. 웨비나를 통해 일상적인 실험실 분석 업무를 위해 특별히 디자인된 Vanquish Core HPLC 시스템을 확인해 보십시오.

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Speakers: Stacy Tremintin Product Manager Thermo Fisher Scientific Ilze Birznieks Product Manager Thermo Fisher Scientific

Understanding the Diversity in HPLC Chromatography Chemistries

In this on-demand webinar, learn about the best chemistries for sample types, and understand the benefits unique selectivity offers to improve resolution in your sample matrices, and decode different phase options available, facilitating efficient method development and eliminating the guess work.

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Speaker: Dr. Ken Cook EU Bio-Separations Expert Thermo Fisher Scientific

Taking Charged Variant Analysis of Therapeutic Proteins to the Next Level

Join scientific experts from NIBRT in Dublin, Ireland and Thermo Fisher Scientific for the latest analytical advances for intact protein characterization.

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Speakers: Mike Baynham, PhD Senior Product Manager LC Columns Thermo Fisher Scientific Rainer Bauder Manager, Technical Applications Chromatography Columns & Consumables, Thermo Fisher Scientific

How to Approach Preparative LC for Compound Purification in the Research and Development Laboratory

In this webcast, learn about the wide variety of phases, hardware, and method development tools available to help you chose the most appropriate preparative HPLC column to maximize your performance.

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Speaker: Craig Dufresne Senior Applications Scientist Thermo Fisher Scientific

Prevent Unwanted Analyte Suppression – Basics of Optimizing Buffer Usage for Ionic Small Molecules and Metabolite Quantitation

Buffers are incredible if they are made and used properly. This presentation will discuss how to optimize your buffers and as a result, your chromatography.

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Speaker: Mark Tracy Senior Applications Scientist Thermo Fisher Scientific

Retention of Polar Substances using Thermo Scientific HILIC and Hypercarb Columns

Polar analytes are complex. Let us teach you about Hypercarb columns, which revolutionized chromatography of polar analytes, and let’s also talk about column chemistries that could “charge” your workflow.

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Speaker: Mark Tracy Senior Applications Scientist Thermo Fisher Scientific

Tips and Tricks for HPLC to UHPLC Method Transfer

This educational webinar will emphasize the benefits of UHPLC to routine quality testing and provide you with takeaway tips on how to effectively understand method transfer in your lab.

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Speaker: Estee Toole Applications Manager Chromatography Columns & Consumables Thermo Fisher Scientific

EASY-Spray Nano LC Column Optimization – Troubleshooting Tips & Red Flags

We’ve learned a lot about troubleshooting EASY-Spray columns and wanted to share some tips with you. Join us to learn how you can optimize your EASY-Spray workflow and signs to watch for that might indicate a problem.

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Speaker: Jessica Nezler Applications Scientist Thermo Fisher Scientific

HPLC Column Troubleshooting Part 2

Column care can directly impact the quality of your chromatography. Learn how to properly care for your columns and how to troubleshoot if things “go astray.” Join us for HPLC column troubleshooting part 2. Your columns will thank you!

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Speaker: Sue Diaz Applications Scientist Thermo Fisher Scientific

HPLC Column Selectivity Made Easy

This presentation will help simplify how to choose the correct phase, particle size, and column dimensions, as well as explain how these choices impact your analytical and workflow needs. We will highlight how varying phases might affect your analysis.

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Speaker: Dr. Heiko Herrmann Thermo Fisher Scientific

Organic Impurity Analysis Workflows

Strategies are shown to improve productivity, reduce cost per sample and gain deeper insights for organic impurity analysis using novel UHPLC and detector technology. How to achieve confirmation, identification and quantification simultaneously with a multi-detector approach.

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Speaker: Dave Hometchko Staff Scientist Thermo Fisher Scientific

HPLC Column Troubleshooting Part 1

Ghost peaks can be scary, shifting peaks can be troubling, and broad peaks can be painful. Let’s talk about some common problems chromatographers face and steps to troubleshoot what’s REALLY going on with your analysis. Join us for the first part of chromatography troubleshooting and learn how to sharpen your skills and your peak shape!

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Speakers: Thomas Pietsch System Manager CDS Takeda Pharmaceutical Co Thomas Günther Project Manager Chromeleon Thermo Fisher Scientific

Benefits of Having an Up-to-Date Chromatography Data System at Takeda Pharmaceutical Company

This webinar will present the initial selection of Chromeleon CDS as a single CDS solution at Takeda, the experiences and lessons learned during the upgrade process and the benefits that Chromeleon 7 CDS brought to the laboratory.

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Speaker: Elaine Corcoran Broughton Laboratories

Broughton Laboratories Case Studies on Pharmaceutical Impurities

In this webinar, Broughton Laboratories presents their work in the area of pharmaceutical impurities focusing on method development and validation of related substances, stability studies and impurity profiling and the investigation of unknown impurities.

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Speaker: Kirsty Mcintyre LGC Standards

Inorganic Impurity Analysis Workflows

We discuss novel and existing inorganic impurities and how ICP-MS can being utilized and optimized to obtain ultimate sensitivity and rapid detection and quantitiation of such impurities. Also how automatic method development can improve productivity.

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Speaker: Dr. Christian Zeine LGC Standards

Overview of Pharmaceutical Impurities and Reference Standards

Dr. Christian Zeine presents an overview of the topic of pharmaceutical impurities including what constitutes an impurity, the various types of impurities, the regulatory guidelines and detection limits and the important points to consider during impurity testing. In addition, briefly introducing why to use reference standards and the main points to consider during their use.

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Speaker: Jane Cooper Senior Applications Scientist Thermo Fisher Scientific

Orbitrap GC-MS - Unknowns discovery workflows for the characterization of e-cigarette liquids

This webinar will share how the Thermo Scientific™ Exactive™ GC Orbitrap™ GC-MS mass spectrometer can confidently characterize the chemical content of electronic cigarette liquids.

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Speakers: Richard Fussell Food and Beverage Vertical Marketing Manager Thermo Fisher Scientific   Fausto Pigozzo Director of Workflow Development Thermo Fisher Scientific

New Analytical Workflow for the Analysis of Anionic Pesticides

This webinar focuses on the extensive optimization and performance of a new validated ion-chromatography triple quadrupole mass spectrometry based workflow for the robust, sensitive and reliable determination of a group of polar anionic pesticides and metabolites at low µg/kg levels, without the need for derivatization, and all in a single analysis.

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Speaker: Ed George Senior Applications Scientist Environmental and Food Safety Thermo Fisher Scientific

Multi-class Veterinary Drug Quantitation with a Comprehensive Workflow

This presentation describes the development and implementation of a comprehensive multi-class veterinary drug method based on LC-MS/MS using a generic QuEChERS sample preparation. The method was validated in bovine muscle, salmon fillet, and milk to demonstrate applicability to a wide range of matrices.

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Speakers: Alessandro Cavaglioni Laboratory Manager ISVEA s.r.l., Poggibonsi, Siena, Italy Debora D’Addona LSMS Application Specialist for the Sales Support Team Thermo Fisher Scientific

Multi-Class Pesticide Quantitation with a Comprehensive Workflow

This presentation describes the development and implementation of a comprehensive multi-class pesticides method based on LC-MS/MS using a generic QuEChERS sample preparation. The method was validated in wine and olive oil to demonstrate applicability to several matrices. The method detection limits obtained were compliant with EU SANTE/11813/2017 guidelines.

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Speakers: Richard Law Senior Applications Specialist, Thermo Fisher Scientific
Fausto Pigozzo Director of Workflow Development Thermo Fisher Scientific

Dioxin Analysis with Triple Quadrupole GC-MS/MS: How to Simplify Complexity While Ensuring Compliance with the Latest EU Regulations

This webcast illustrates the development and capability of a Dioxin Analyzer using Advanced Electron Ionization (AEI) for ultra-high sensitivity Dioxin Analysis with Triple Quadrupole GC-MS/MS. Learn how to simplify complexity while ensuring compliance with the latest EU regulations.

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Speakers: Matthew MacLennan, Ph.D. Senior Scientist and Director of LC/MS Pacific Rim Laboratories
Richard Jack, Ph.D. Senior Director of Vertical Marketing Thermo Fisher Scientific

Understand Product Quality Attributes of Biotherapeutics through a Multi-Attribute Method (MAM) Lab-of-the-Future

Watch this webinar to learn how MS-based MAM provides simultaneous detection, identification, quantitation and quality control (monitoring) of PQAs. The webinar covers how a dedicated team at Pfizer developed a multi-site “Lab-of-the-Future” for streamlined MAM analyses.

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Panelists: Darren Barrington-Light Senior Product Marketing Manager Enterprise Chromatography Data Systems Thermo Fisher Scientific Holger Franz Manager, HPLC Product Management Thermo Fisher Scientific

Simple to the CORE – The new Thermo Scientific Vanquish Core HPLC system

Built upon the innovative Vanquish platform, the new Vanquish Core HPLC system provides exceptional analytical precision, detector sensitivity, and operational simplicity to enable unprecedented reliability and robustness. Designed specifically for routine analysis laboratories. Addressing the benefits of our exceptional technology.

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Speaker: Dr. Sheng Zhang Director, Proteomics Facility and Metabolomics Facility Cornell University

High throughput identification of novel tomato flavonoids by a structure-based profiling and annotation Workflow

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Speakers: Lee Ferguson Associate Professor Duke University Abigail Joyce Research Scientist Duke University

Latest mass spectrometry-based trends for identifying and quantifying unknown PFAS compounds

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Speaker: Jesper Olsen Professor, University of Copenhagen

Improving Proteome Coverage and Peptide Identification Rates in Short LC Gradients

In this webcast, the speaker will present first impressions of the Thermo Scientific Orbitrap Exploris 480 mass spectrometer equipped with a Thermo Scientific FAIMS Pro interface for shotgun proteomics. The performance of the new instrument is evaluated in data-dependent acquisition (DDA) and data-independent acquisition (DIA)* modes with fast scanning HCD methods in combination with front-end Field Asymmetric Ion Mobility Spectrometry (FAIMS).

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Ion Chromatography Tips and Tricks

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Ion Chromatography Column Selection

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Lab Validation and Performance Requirements for the Analysis of PFAS Compounds in Drinking Water

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Perform Like a Pro: Fast ICP-OES Analysis with the Latest Advances

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Thermo Fisher Scientific

A Virtual LCMS Conference Designed for the Masses: your fast track to confident results

Welcome to the Thermo Fisher Scientific virtual LCMS Conference – an exclusive event on state-of-the-art mass spectrometry with a focus on Orbitrap technology and beyond. The switch between exploration and targeted quantitation has never been easier. Scale up your research and translate your results more rapidly and simply than ever before.

Join us at our virtual conference to:
• Attend plenary presentation by Professor Alexander Makarov – “Designing the Smallest Ever Orbitrap Mass Spectrometer for New HRAM Applications”.
• Learn and gain valuable insights from mass spectrometry experts about Orbitrap mass spectrometry technology and the applications it enables.
• Explore the LCMS portfolio and meet the expanded Orbitrap Exploris MS systems in our Exhibit Hall and dedicated booths.
• Venture into our poster vault for numerous poster presentations.
• Interact and discuss your questions with fellow scientists and experts online in live Chat Chamber. Dedicated live chats are also available in English, 日本語, 한국어 and 繁體中文.
• Challenge yourself in our recreation room available after the conference to win exclusive giveaways.
• Receive a Certification of Attendance for attendees who join us during our live virtual conference**.

Conference presentations will be available in English, 日本語 and 한국어.

Virtual LCMS Conference Agenda

Explore sessions tailored to your interest:

23rd June 2020 (Tuesday)
IST GMT +8 JST/KST AEST Agenda

 

1030

 

1300

 

1400

 

1500

 

Designing the Smallest Ever Orbitrap Mass Spectrometer for New HRAM Applications
Professor Alexander Makarov
Thermo Fisher Scientific

 

 

 

 

1110

 

 

 

 

1340

 

 

 

 

1440

 

 

 

 

1540

 

Your fast-track to confident results: Thermo Scientific Orbitrap Exploris product family expanded
Dr. Thomas Moehring
Thermo Fisher Scientific

 

Demonstrating the new Orbitrap Exploris 240
Dr. Daniel Lopez-Ferrer
Thermo Fisher Scientific

 

Demonstrating the new Orbitrap Exploris 120
Dr. Ed George
Thermo Fisher Scientific

  English Japanese Korean

 

1140

 

1410

 

1510

 

1610

 

Proteomics on Orbitrap Exploris 240 MS - Moving beyond peptide IDs - A New, Versatile and Robust Compact Benchtop Orbitrap For Quantitative Proteomics Applications
Dr. Peter Mowlds
Thermo Fisher Scientific

 

Analysis of Nitrosamines on Thermo Scientific Q Exactive Plus and Thermo Scientific Orbitrap Exploris 120 
Dr. Olaf Scheibner
Thermo Fisher Scientific

 

DIAによる超深度プロテオーム解析への挑戦 
川島 祐介 (Dr. Kawashima Yusuke)
公益財団法人かずさDNA研究所 (Kazusa DNA Research Institute)

 

2020 ASMS에서 출시된 Orbitrap Exploris 120/240 을 이용한 다양한 응용사례 소개
Ms. Hweewon Koh
Thermo Fisher Scientific 

 

1220

 

1450

 

1550

 

1650

 

Orbitrap and the IDX platform: The Foundation of Scientific Confidence, Versatility and Excellence for RASL Dr. Paul Zahra
Racing Analytical Services Limited (RASL)
Co-presenter Dr. Steve Binos
Thermo Fisher Scientific

 

Next-generation Orbitrap Exploris Mass Spectrometers for sensitive Qualitative and Quantitative PFAS analysis
Dr. Neville Llewellyn
Thermo Fisher Scientific

 

網羅的な同定から定量まで、Orbitrap Exploris 240によるプロテオミクス アプリケーションのご紹介
渡邊 史生
(Mr. Watanabe Shio)
サーモフィッシャーサイエンティフィック株式会社
(Thermo Fisher Scientific)

 

Orbitrap Exploris シリーズによる定量アプリケーションのご紹介
山元 良馬
(Mr. Yamamoto Ryoma)
サーモフィッシャーサイエンティフィック株式会社
(Thermo Fisher Scientific)

 

정밀의학 (precision medicine) 을 위한 임상단백질학 연구 소개
Dr. Kyunggon Kim
Asan Medical Center (Clinical Proteomics Core Laboratory / University of Ulsan)

 

1250

 

1520

 

1620

 

1720

 

MS-based Clinical Proteomics Workflow from Discovery to Validation
Dr. Sanjeeva Srivastava
Indian Institute of Technology Bombay, Mumbai 

 

Identification of Bioactive Compounds using LC-HRAM-MS for Food Authentication
Dr. Hong-Jhang Chen
National Taiwan University

 

探索からルーチンまでカバーするバイオ医薬品特性解析ソリューションのご紹介~ウイルス、抗体から核酸まで~
肥後 大輔
(Mr. Higo Daisuke)
サーモフィッシャーサイエンティフィック株式会社
(Thermo Fisher Scientific)

 

新製品のご紹介:低分子定性に有用な機能とソフトウエアのご紹介
石橋 愛実
(Ms. Ishibashi Megumi)
サーモフィッシャーサイエンティフィック株式会社 (Thermo Fisher Scientific)

 

HRAM Orbitrap 기술을 이용한 프로테오믹스 연구 소개
Dr. Jong-Seo Kim
Seoul National University (Center for RNA Research, IBS)

 

1320

 

1550

 

1650

 

1750

 

Please proceed to Exhibition Hall / Poster Vault / Recreational Room

 


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LC-MS Hybrid Exploris and Q Exactive product Families
LC-MS Tribrid Family
LC-MS Triple Quad MS
LC-MS Ion Trap MS
LC-MS Medical Devices
Multichannel LC
LC-MS Software
Sample preparation - reagents and standards
GC/GC-MS/GC-QQQ
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HPLC and UHPLC
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Inorganic Mass Spectrometry
Automated Sample Preparation
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